Dosing & Administration
ZELVARA is administered as an intravenous infusion with weight-based dosing calculated using body surface area (BSA). A loading dose is given on Cycle 1 Day 1, followed by maintenance dosing every 3 weeks.
Dosing Calculator
Enter weight and height to calculate dose
BSA calculated using the Mosteller formula: BSA (m²) = √((height × weight) / 3600). For informational purposes only — verify all calculations independently.
Recommended Dosing Schedule
| Cycle | Dose | Route | Duration | Notes |
|---|---|---|---|---|
| Cycle 1, Day 1 | 800 mg/m² | IV infusion | ~3.5 hours | Administer premedication 30 minutes prior |
| Cycle 2+, Day 1 | 600 mg/m² | IV infusion | ~2.5 hours | Continue until disease progression or unacceptable toxicity |
Recommended Premedication
| Medication | Dose | Route | Timing |
|---|---|---|---|
| Dexamethasone | 12 mg | IV | 30 minutes before infusion |
| Ondansetron | 8 mg | IV | 30 minutes before infusion |
| Diphenhydramine | 25-50 mg | IV or PO | 30 minutes before infusion (optional) |
Dose Modification Guidelines
| Toxicity | Grade | Action |
|---|---|---|
| Nausea/Vomiting | Grade 3 | Withhold until ≤Grade 1. Resume at 600 mg/m² (or 400 mg/m² if already reduced). |
| Nausea/Vomiting | Grade 4 or recurrent Grade 3 | Permanently discontinue ZELVARA. |
| Infusion-Related Reaction | Grade 1-2 | Interrupt infusion. Resume at 50% reduced rate upon resolution. |
| Infusion-Related Reaction | Grade 3-4 | Permanently discontinue ZELVARA. |
| Other nonhematologic | Grade 3 | Withhold until ≤Grade 1. Resume at same or reduced dose per clinical judgment. |
| Other nonhematologic | Grade 4 | Permanently discontinue ZELVARA. |